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In the SURPASS-2 trial published in the New England Journal of Medicine, tirzepatide at 15 mg produced an average weight loss of 11.2 kg compared to 5.7 kg with semaglutide 1 mg over 40 weeks

10.1152/jappl.1987.63.1.152 J Appl Physiol

Ultrasonic cavitation, RF, or lipolysis treatments disrupt fat cell membranes releasing stored fatty acids into the interstitial fluid

Rarely, dose reduction is necessary

Tirzepatide is available as Mounjaro (for type 2 diabetes) and Zepbound (for chronic weight management), both containing the same active ingredient administered as a once-weekly subcutaneous injection