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Featuring insights with two-time guest Kyal Van Der Leest, a pioneer in the field, we examine how niche peptides are being used to modulate everything from cognitive function to inflammation

[] Exercise can physiologically upregulate central BDNF expression, [] while the small-molecule TrkB agonist 7,8-dihydroxyflavone mimics BDNFs anorexigenic effects

Gibbs, J., Young, R

MOTS-c is a peptide

This level of control is impossible with oral forms where absorption can vary wildly based on what someone ate, their gut health, and individual metabolism

Unlike GLP-1 receptor agonists (like semaglutide), cagrilintide targets amylin and calcitonin receptors in the brainstem