IBS is also associated with fungal microbiota imbalance, especially overgrowth of Candida ( Akkermansia muciniphila can exacerbate the colonization of Candida tropicalis ( Escherichia coli in the gut significantly affects the hyphae and biofilms formation of Candida , and upregulates pathogenic genes such as ALS3 and HWP1 (Farrokhi et al., 2021)
The evolution of DDSs from passive carriers to intelligent, patient-centric platforms signifies promising progress in gout and hyperuricemia management, yet substantial challenges in clinical validation, scalability, and long-term safety persist, underscoring the need for sustained interdisciplinary efforts to fully realize their therapeutic potential
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The amino acid glutathione is a naturally occurring protein already in your body
We showed that mice fed a high-fat diet (HFD) for 12 weeks developed hepatic steatosis and liver injuries, which were associated with not only TNF overproduction but also hepatic glutathione dysregulation, characterized by GSH reduction and GSSG elevation
doi: 10.1016/j.immuni.2019.11.009 7 MillsELKellyBLoganACostaASHVarmaMBryantCEet al
