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Ursodeoxycholic acid exerts farnesoid X receptor-antagonistic effects on bile acid and lipid metabolism in morbid obesity

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Benton CB, Takahashi K, Bose P, Wang F, H-C C, Zheng X, Zhang J, Wang X, Su X, Montalban-Bravo G, Issa GC, Daver N, Jabbour EJ, DiNardo CD, Bueso-Ramos CE, Patel K, Kornblau SM, Konopleva M, Borthakur G, Kadia TM, Cortes JE, Ravandi F, Andreeff M , Garcia-Manero G, Futreal A, Kantarjian H

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Early pharmacokinetic studies suggested that when standard, unprotected glutathione was ingested, it was rapidly cleaved into its constituent amino acids (glutamate, cysteine, and glycine) by digestive enzymes like $\gamma$-glutamyltransferase and harsh stomach acids

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