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Despite their effectiveness, these drugs have been linked to severe gastrointestinal complications and other potential risks, underscoring the importance of fully understanding their effects

Once reconstituted, peptides should be refrigerated at 4C and used within 30 days

Similarly, of the numerous adverse effects tracked in LEADER, only GI events were significantly higher in those treated with liraglutide (acute gallstone disease, nausea, vomiting, and diarrhea)

Therefore, considering the overlapping yet distinct roles of insulin and IGF-1 in the brain, disruptions in their signaling pathways due to IR may contribute to the neurobiological mechanisms underlying depression in individuals with T2DM