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Antibiotics, particularly tetracyclines, anticonvulsants like phenobarbital, and certain chemotherapy agents may interact negatively with the B vitamins

Patients with hepatic impairment already have complex coagulation profiles, often with both pro-thrombotic and hemorrhagic tendencies

Animal studies are promising, showing enhanced healing of connective tissue and protective effects on the digestive tract

For a 70kg person at the high end: 70 x 40 = 2,800mg per day

Under these conditions it can remain stable for approximately 18 to 24 months

The advisory committee makes recommendations, but the FDA makes the final decision