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** Based on the treatment policy estimand: treatment effect regardless of if patients stayed on treatment or took other weight loss therapies
"Semaglutide and Cardiovascular Outcomes in Obesity without Diabetes." (SELECT) N Engl J Med
Since the mid-1960s, this substance has been used in Japan in the treatment of heart diseases
doi: 10.1002/cac2.12138 9 CalinGADumitruCDShimizuMBichiRZupoSNochEet al
Balanced Feedback While most Brello reviews are glowing, some users mention that GLP-1 medications can take time to adjust to and may cause mild side effects (like nausea) early on
GLP-1s vs Traditional Weight Loss Medications Older options like phentermine, orlistat, or naltrexone-bupropion typically produce 5-10% weight loss compared to 15-22% with GLP-1 medications
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