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People with certain medical conditions should avoid glutathione IV therapy, including those with severe kidney disease, active liver problems, or certain autoimmune disorders

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The side effects that do exist are narrow and well-characterized: gastrointestinal upset at higher oral doses, a distinctive fishy body odor from a carnitine metabolite, and one genuinely debated caveat an indirect cardiovascular signal involving the gut-derived metabolite TMAO

Proposed mechanisms include fibroblast migration and proliferation, modulation of growth-factor signalingincluding EGF and VEGFand changes in reticulin and collagen-fiber formation at injury sites