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A common epitalon cycle is one month on followed by three months off a total of three cycles per year

Those with diseases that affect the gut, such as Crohns disease or celiac disease, are also at risk ( Summary Those at greatest risk of vitamin B12 deficiency are vegans and vegetarians, who get little to no B12 from the diet

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This presents a challenge for individuals following vegetarian or vegan diets, as plant foods do not contain reliable amounts of B12