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Mechanistically, in contrast with the canonical doctrine that GSH globally maintains proteins in a reduced state, we show that GSH depletion selectively oxidizes and promotes the degradation of fatty acid synthase (FASN), a key regulator of lipid metabolism

10.1159/000485089 19 HongJ

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On the face, the main substances described for fat reduction are phosphatidylcholine and sodium deoxycholate [13-15]