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Timing considerations include ensuring the patient has tolerated the current dose well, with resolution or stabilization of any initial gastrointestinal symptoms
It also means that the dose-response curve is steeper, which reinforces why accurate calculation and gradual escalation are non-negotiable
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Buchman A
31 The second study enrolled 60 patients with varying degrees of renal impairment and administered 5 mg of oral semaglutide daily for the first 5 days, followed by a 10-mg dose once daily for the remaining 5 days of the study
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