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By blocking this enzyme, sitagliptin increases incretin levels, which in turn stimulate insulin release from the pancreas in a glucose-dependent manner and reduce glucagon secretion

Some users find that eating a small amount of bland food, like crackers or toast, 30 minutes before injection reduces nausea

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The most noticeable benefit after only a few hours of initial injection is increased energy

However, their active ingredient, tirzepatide, may be compounded (custom-made) by a licensed pharmacist