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Cytochromes P450 2E1 (CYP2E1) and 3A4 (CYP3A4) convert paracetamol to a highly-reactive intermediary metabolite, N-acetyl-p-benzo-quinone imine (NAPQI).[31][32][33] Under normal conditions, NAPQI is detoxified by conjugation with glutathione
Every spring for the past five years, I lose about six weeks of my life to this misery
Yrek B, Kasapkara CidS: two patients diagnosed as succinate dehydrogenase deficiency: case report
Because GSH may oxidize after collection and GSSG is typically much less abundant, sample handling can substantially alter the apparent balance
Laboratory Methods in Histopathology (American Registry of Pathology, 1992)
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