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Purtell advises focusing on achieving sustainable weight loss rather than fixating on a specific number on the scale

GLP-1 crosses the blood-brain barrier in limited amounts, but more importantly, it activates vagal afferent neurons that communicate with central appetite centers

10.1038/s41380-020-00957-3 28 HolstJ

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Gomez-Arbelaez D, Bellido D, Castro AI, Ordoez-Mayan L, Carreira J, Galban C, et al