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When administered orally, it is hydrolysed by the gastric juices and further undergoes degradation by the liver enzyme, and the resultant bio-availability is low

One way of screening for sensitivity to primaquine is based on the observation that the glutathione concentration of erythrocytes from sensitive subjects is somewhat lower than that of control subjects, and falls considerably on incubation with acetylphenylhydrazine

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Metabolic homeostasis and the cellular redox systems are delicate systems that differ in subcellular compartments and depend on the physiological condition of the animal/cell (e.g., circadian rhythm, cell cycle stage, disease pathology)