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Due to skin hypoxia (small concentration of oxygen in the skin), consumption is described by a linearized Michaelis-Menten law and we get: where is the 2D Laplacian (see the Supplementary), n and c are now the concentration averaged along the epidermis depth, n s is a typical nutrient concentration necessary to maintain the homeostatic state of the skin

Kodaka Y, Futagami S, Tatsuguchi A, Yamawaki H, Sato H, Hashimoto S, et al