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However, three important functions are altered in people taking semaglutide that may be the primary contributing factors to weight loss

In a phase II study of the long-acting GLP-1RA efpeglenatide (4 mg once weekly, 6 mg once weekly, 6 mg once every 2 weeks, and 8 mg once every 2 weeks), patients with obesity and without diabetes had statistically significant reductions in body weight compared with placebo after 20 weeks of treatment (differences in least squares means were 6.3 to 7.2 kg

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week 2), pre-diet baseline symptom severity category (minimal/mild, moderate, or severe), and the challenge material * symptom severity category interaction

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