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The direct effect of GLP-1 on adipose tissue has been demonstrated in many studies

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Diarrhea affects fewer men but can occur, particularly with combination therapy

Peripheral neuropathy (PN) In PN, nerves in the arms and legs are damaged, leading to a variety of symptoms, including pain, burning, numbness, tingling, loss of balance and co-ordination, and muscle weakness

Naltrexone/Bupropion: Nausea, constipation, headache, vomiting, and dizziness

These ranges are research planning, not personal dosing recommendations, and no published human Phase 2 or Phase 3 dose-finding trial exists