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After 1 day of infection, the number of bacterial colonies increased from 10 5 to 10 6 CFUs, indicating that the infection model was successfully established

Common adverse effects of GLP-1 receptor agonists include: Gastrointestinal symptoms (nausea, vomiting, diarrhoea, constipation) Injection site reactions Headache Fatigue Dizziness Important safety considerations include: Risk of hypoglycaemia when used with insulin or sulfonylureas (dose reduction of these agents may be needed) Potential worsening of diabetic retinopathy with semaglutide in patients with pre-existing retinopathy [18] Risk of dehydration and acute kidney injury from persistent vomiting or diarrhoea Pancreatitis, gallbladder disease, and potential thyroid C-cell tumours (observed in rodent studies, though human relevance remains uncertain) [19] [20] Patients should be counselled about persistent severe abdominal pain as a potential warning sign of pancreatitis requiring immediate medical attention

American College of Sports Medicine

People with a personal or family history of a medical condition called multiple endocrine neoplasia type 2 (MEN2) or medullary thyroid cancer should not take Wegovy and other weight loss drugs from the same drug class

The reviewer GM declared a shared affiliation, with no collaboration, with the authors to the handling editor at the time of the review

ebei, B., Nikoli, V., Sikiri, P., Seiwerth, S., oa, T., Patrlj, L., Grabarevi, ., Ruman, R., Petek, M., Konjevoda, P., Jadrijevi, S., Perovi, D., & laj, M