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Another promising molecule, RITA (reactivation of p53 and induction of tumor cell apoptosis) has been shown to prevent the interaction of p53 and MDM2 and to induce p53 accumulation in tumor cells 57
Anyone pregnant, breastfeeding, or with a diagnosed metabolic, hepatic, or endocrine condition falls entirely outside any studied context and should not be a subject of self-directed use
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What follows is an honest map of where the mechanism is solid, where the evidence stops, and what better-evidenced options are sitting in the same slot
However, similar to CM there is nearly no coincidence of NRAS and BRAF missense mutations, suggesting functionally redundant NRAS and BRAF mutations in MM despite more variable mutational locations
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