Patients with renal impairment require particular caution with metformin, as reduced kidney function increases the risk of lactic acidosis, a rare but serious complication
The appetite suppression during treatment creates an optimal window to practice portion control, reduce ultra-processed food consumption, and build consistent exercise routines

Multiple molecular mechanisms, activated by inflammatory mediators, contribute to the progression of HS.34,35 The prevalence of DT2 is higher in subjects with HS than in the general population.36 HS is also associated with other conditions traditionally linked with obesity, such as metabolic syndrome, polycystic ovarian syndrome, and inflammatory bowel disease,3739 and patients with HS are exposed to higher CVR than the general population.40 Obesity negatively impacts the response of patients to the main treatments for HS (Table S1 additional information).15 Advantages associated with weight loss in patients with obesity and psoriasis or hidradenitis suppurativa In addition to better response to treatments for inflammatory dermatoses, other arguments justify the desirability of patients with obesity and PsO or HS to lose weight
Keep a close record of how you feel during the first several weeks
No documented interaction exists in UK prescribing information or published clinical studies
This is one of the most widely used peptide stacks in the research community