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As we had previously demonstrated in cell lines (16), total glutamate and glutathione levels declined in primary cortical neurons treated with acivicin (Fig
However, given the lower intracellular GSH:GSSG ratio after IL-13 stimulation, it is difficult to determine the proportionate role that loss of GSH plays in downstream T2-pathway mRNA/protein expression
Pereira-Rodrigues N, et al
Bim, bad, and bax: a deadly combination in epileptic seizures
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The glutathione moieties of GSSR and GSH have to interact with different protein areas as a result of the S N 2 geometry of both half-reactions of the ping pong bi-bi mechanism (Fig
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