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Following the examination of microsomal metabolism, 24-month old male Sprague-Dawley rats weighing approximately 290-450 grams were utilized for the purpose of behavioral studies

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In vitro and in vivo studies demonstrate an IGF-1 deficiency can deregulate lipid metabolism, increase the risk of cardiovascular disease, and compromise the metabolic profile of diabetic patients

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The sequences of primers used are listed in Additional file 2: Table S1