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On days without workouts, the morning is a suitable time

The effects tend to be modest, and the research is often limited in size or quality

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Because these are dietary supplements, they skip FDA pre-market safety review

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The study in Molecular Nutrition and Food Research demonstrated that nicotinamide supplementation in mice on a high-fat diet reduced body weight gain, increased energy expenditure, and upregulated genes involved in thermogenesis and fat oxidation, including PPARalpha and PGC1alpha