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GLP-1 RAs Hold Promising Potential for Reduction of Cardiometabolic Risk Factors additional benefits : Brain: Appetite suppression, nerve protection, and decreased neuroinflammation Heart: Decreased blood pressure (systolic and diastolic), reduced total cholesterol levels, lowered endothelial dysfunction, and increased heart rate Liver: Decreased glucose production Pancreas: Increased insulin secretion, decreased glucagon secretion, B islet cell proliferation GI Tract: Decreased gastric emptying Because these drugs cause weight loss, it is not clear whether the GLP-1 RAs or the weight loss reduces cardiometabolic risks
A Systematic Review and Meta-analysis
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For patients with concerns about gastrointestinal discomfort, agents with lower associated risks such as dulaglutide, cagrilintide, or oral semaglutide may be preferable
For more details regarding LoCITT, including how to participate in this or subsequent trials, please visit The study team will host a webinar on November 5, 2025, 11 a.m
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