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However, retatrutide may have superior benefits for insulin resistance and glycemic regulation , due to: Enhanced insulin sensitivity from GIP agonism Reduced hepatic glucose output from glucagon signaling modulation Improved beta-cell function Clinical Insight: Retatrutide reduced fasting glucose and A1C levels with similar or better efficacy than tirzepatide in early trials

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Blood Sugar Control Both compounds significantly improve glycemic control with 1.5 to 2 percentage point HbA1c reductions

Rice DC, Lee JH, Jimenez C, Eapen G, Stewart J, Hofstetter WL, Mehran R, Vaporciyan AA, Walsh GL, Swisher , SG

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