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Since exercise contributes significantly to long-term success with any weight management approach, this indirect benefit compounds over time

These changes can include limited mobility, pain, fatigue, and changes in appearance

10.1186/s12933-019-0860-y 85 MaT.TianX.ZhangB.LiM.WangY.YangC.et al (2022)

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Muscle that is lost and not recovered has downstream consequences: a slower metabolic rate, reduced insulin sensitivity, weaker bones, and declining physical function over time

The neonatal-onset form of the disease is the more common form of propionic acidemia