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A: Alternatives to estradiol patches include FDA-approved transdermal gels and sprays, oral estradiol (with a different clot-risk profile), vaginal estrogen preparations for genitourinary symptoms, and compounded transdermal estradiol creams from PCAB-accredited pharmacies

Inhibiting pyroptosis with Caspase-1 inhibitor VX-765 effectively suppressed the occurrence of pyroptosis in HK-2 cells, as well as the tubular damage, renal inflammation and DKD progression in diabetic mice (168)

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