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In fact, NADH is an inhibitor of the TCA enzyme isocitrate dehydrogenase 93 , a protective mechanism to prevent overloading of the ETC and excessive ROS generation

Collectively, current evidence from RCT subgroups, observational studies, and mechanistic data supports the biological plausibility and clinical relevance of complementary cardiovascular and kidney benefits with combined SGLT2i and GLP-1RA therapy (Table 2)

Once the goal weight is achieved, they should increase their moderate aerobic exercise to 200 to 300 minutes a week for maintenance

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