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For many, this is the first time they feel freedom from constant food cravings or food noise. Clinical research has consistently shown that GLP-1s are highly effective at reducing body weight when combined with lifestyle changes
In addition, long-term use of GLP-1RAs may also have potential safety risks, such as pancreatitis (Shetty et al., 2022) and thyroid diseases ( 6 Discussion T2DM is a chronic disease characterized by hyperglycemia, which eventually leads to microvascular damage and macrovascular events, as well as complications related to peripheral vascular diseases
Moreover, the levels of 5-hydroxytryptamine, -aminobutyric acid (GABA) and their receptors, as well as glutamate receptors are reduced in patients with AD (4246)
255,256 Whilst international regulators (e.g
Why GLP-1 Side Effects Matter Many gastrointestinal effects are mild to moderate and become less noticeable as the body adjusts
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