Adipocyte and hepatocyte cell models probing GLP-1R-mediated insulin secretion, gastric-emptying signaling, and lipid-metabolism pathways
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Pelvic floor dysfunction, which affects how the muscles involved in bowel movements work, can also play a role
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In addition, PVH GLP-1R knockout in juvenile mice led to increased adult body weight and food intake with no changes in energy expenditure, suggesting potential compensatory adaptation during development [94]