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These inhibitors, which aim to increase the levels of neurotransmitters in the brain, could be more effective when used in conjunction with polyphenols, which protect neurons from oxidative damage and improve overall brain health
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The report also noted that a large Phase IIb trial (ZUPREME-1) is underway with enrolment expected to be completed in the first half of 2025 and that a second Phase IIb trial (ZUPREME-2) is planned to evaluate petrelintide in individuals with type 2 diabetes
It is important to note that while serum accumulation of MMA and Hcy are sensitive biomarkers of vitamin B 12 deficiency in humans 26 , this is not the case in mice 37,38
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