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Start medication at low dose (semaglutide 0.25 mg weekly or tirzepatide 2.5 mg weekly)

92% of patients who lost 5%+ by week 12 went on to achieve at least 15% total weight loss by week 48

While this extended half-life reduces dosing frequency, it also creates more constant GH rise that may not keep natural pulsatile patterns as effectively

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Are you administering once per day before bed to maximize the natural GH pulse, or are you using multiple smaller doses to maintain a steadier elevation

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