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A specific and critical trajectory for future research is the estrogen-gut-brain axis. Clinical and preclinical studies are being conducted to show that estrogen deficiency not only affects the gut and skeleton but also distorts the three important network constellations of the organism, which include the hypothalamus and the pituitary in the case of PMW, functional hypothalamic amenorrhea, and premature ovarian failure, and so on

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Possible process of compromised immunotolerance in women is asymmetrical X chromosome inactivation (XCI), which cause evade from the presentation of X-linked self-antigens in the thymus and following deterioration of T cell tolerance

When decorin production dips, scar tissue forms

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