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This function of GLP-1 under an inflammatory condition shows the therapeutic possibility of GLP-1 in the depressive brain accompanied by neuroinflammation

The Monday-Thursday schedule creates a roughly 72-hour gap between injections, which maintains adequate drug levels while providing enough spacing to avoid excessive accumulation

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Other reported effects included: Transient fatigue Reduced appetite (therapeutically desirable in the context of weight loss) Mild injection-site reactions Altered skin sensations or cutaneous hyperesthesia (reported in ~7% of participants, mild and non-serious) Serious adverse events were rare and occurred at similar rates in the retatrutide and placebo groups (approximately 4%)

60 HuangY.YuanK.TangM.YueJ.BaoL.WuS.et al (2021a)