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Figures out that the next 10-20 years of their life will be costing anywhere from ~$120,000 to ~$280,000 in injections
The base case, based on the company's prior pattern with tirzepatide, is that filing follows within roughly six months of TRIUMPH-1 topline
SURMOUNT-1 (Jastreboff et al., NEJM 2022, n=2,539) showed the same pattern: nausea and diarrhea were highest in the first three months of the 72-week trial and fell significantly by weeks 20 through 24
Press Release, Aug 26, 2025
Dietary fibre, particularly soluble fibre, appears to enhance GLP-1 production by promoting the formation of short-chain fatty acids through bacterial fermentation in the colon, which may then stimulate L-cells
FDA minutes will settle it
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