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It does make me not hungry which is the best part

It simultaneously activates three key metabolic receptors: GLP-1 (glucagon-like peptide-1), GIP (glucose-dependent insulinotropic polypeptide) and the receptor at glucagon This triple synergistic action makes it one of the most studied peptides in research on obesity and metabolic disorders

Retatrutide works through three receptor systems simultaneously

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[11] [12] Women of childbearing potential should be aware that tirzepatide may reduce the effectiveness of oral contraceptives, particularly during the first 4 weeks after initiation and after each dose escalation