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Novo Nordisk announced FDA acceptance of their New Drug Application (NDA) for a 25 mg oral version of Wegovy for two new indications: (1) chronic weight management in adults living with obesity or who are overweight with at least one comorbid condition, and (2) to reduce the risk of MACE in adults with overweight or obesity and established CVD

As a member of the mammalian sirtuins family, Sirt3 is a mitochondrion-localized histone deacetylase, which is highly expressed in mitochondria-rich tissues and plays a key regulatory role in the development of glioblastoma [87]