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It is important to note that serum Se (S-Se) does not directly reflect the concentration of Se in tissues, and even normal S-Se content does not exclude the possibility of Se deficiency in the thyroid (119, 120)

Generation of KO and knockdown cell lines Optimized sgRNA oligonucleotides 64 were cloned into lentiCRISPRv2 (ref

The results found the IGF-1 phase to be associated with improvement in social impairment and restrictive behaviors [14]

Washed beads were resuspended in 100 L of 50 mM HEPES buffer (pH 7.4) and sequentially reduced with TCEP (200 M) and re-alkylated either with IAM (400 M) Procedure A or with IAM-TPP (400 M) Procedure B for 30 min at RT in the dark

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The mechanism is not well established it may relate to individual sensitivity, dehydration coinciding with supplement use, or other unrelated factors