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Nonapoptotic functions of FADD-binding death receptors and their signaling molecules

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Fan Y, Zhu M, Shabala S, Li C, Johnson P, Zhou M

Dimerization with stimulation of MC3R leads to a twofold amplification of MC3R-induced cAMP accumulation (top), while the GHSR1a protomer shows a ligand-dependent as well as ligand-independent 40% reduction in Ca 2+ accumulation when dimerized with MC3R (bottom)

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Neuroendocrine Regulation Corticotropin, LH, and GH DSIP reduces basal corticotropin (ACTH) levels a consistently replicated finding across multiple studies and stimulates secretion of luteinising hormone (LH) and the release of somatotropin (GH) and somatoliberin (GHRH)