Within the CNS, PYY exerts its effects on satiety via actions in the hypothalamus, specifically the ARC of the hypothalamus
It is an antioxidant that improves brain functions, energy, physical performance, and helps with sperm mobility
Pre-existing inborn errors of sulfur-amino-acid metabolism (e.g., homocystinuria) represent an absolute contraindication because parenteral methionine can exacerbate elevated homocysteine concentrations and associated thrombotic risk
The modifications reduce binding to IGF binding proteins, extending its biological half-life relative to native IGF-1
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