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IGF-1 plays a central role in tumor development by stimulating proliferation and inhibiting apoptosis in cancer cells. Pollak, Nature Reviews Cancer Acromegaly-Like Symptoms (Rare) In extremely high or prolonged dosesespecially when stacked with HGHIGF-1 may contribute to: Bone thickening (jaw, forehead, hands) Enlarged soft tissue Headaches or carpal tunnel symptoms These side effects mimic acromegaly , a condition caused by excessive GH/IGF-1 signaling
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Results showed that a twice daily IGF-1 dose of 120mcg/kg produced almost identical effects as that of a twice daily 80mcg/kg dose [18]
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Thus, repeated intravenous L-carnitine supplementation may produce a greater increase the total carnitine concentration in skeletal muscle than oral L-carnitine during the modified fasting period
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