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*Correspondence: Jing Yao, [email protected] These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

This is perhaps due to the variability in the quality of products that are being sold, but perhaps also due to our current lack of understanding of its activity in humans

Lee J, Pellegrini MV

Folic acid deficiency can be caused by poor diet, alcoholism, surgery, pregnancy, and malabsorption-causing digestive disorders such as Crohns and celiac diseases

Sudden changes in diet can lead to occasional discomfort, so slowly incorporating new foods allows your dog's digestive system to adjust and supports normal GI health and function

The evidence for its broad healing claims has stayed largely unproven, mostly in animal and cell studies, while the compound found a second life among bodybuilders and biohackers and, more recently, within the Make America Healthy Again movement