Why Gastric Bypass Still Has a Role Despite the success of GLP-1s, gastric bypass surgery remains an important option for certain patients
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Module 2 maps the metabolic terrain hormonal status (HRT, thyroid), chronic inflammation, gut health, and micronutrient deficiencies and covers the emerging GLP-1 and HRT synergy data, including Castaneda (2025) ENDO data showing MHT users on tirzepatide lost significantly more weight at 15 months
Through its dual insulinotropic and glucagonotropic effects on stabilizing glucose levels, GIP could provide a buffer against hyperglycemia when large amounts of glucose are consumed and mitigate reactive hypoglycemia, especially after meals with high fat content
Acting on insulin and glucagon levels, incretins, and thus TZP, may have indirect effects also on the liver and muscle
The hormonal fluctuations can trigger tension headaches or migraines in some individuals