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2015 measured permeation through human skin samples held in a Franz cell apparatus, not living skin on a living person 3

Physiologically, at the cellular level, Mg 2+ is involved in metabolic pathways acting as an enzyme cofactor, contributes to the regulation of membrane stability, regulates ion channels, and acts as an intracellular signal [200, 201]

AB: Methodology, Supervision, Writing original draft

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The influence on the BPC-157 dopamine system, in particular, may explain some of the behavioral effects observed in animal studies, including antidepressant-like and anxiolytic-like activities

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