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Abbreviations 1MT: 1-methyl-tryptophan 3HAA: 3-hydroxyanthranilic acid 3HK: 3-hydroxykynurenine 5-HT: Serotonin 7nAChRs 7: nicotinic acetylcholine receptors AHR: Aryl hydrocarbon receptor AMPAR: -amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor BBB: Blood brain barrier BCG: Bacile Calmette-Gurin BDI-II: Beck Depression Inventory, 2nd edition BDNF: Brain-derived neurotrophic factor BSSI: Beck Scale for Suicidal Ideation CDRS-R: Childrens Depression Rating Scale-Revised CNS: Central nervous system ESBA: (S)-4-(ethylsulfonyl)benzoylalanine GBA: Gut-brain axis HAMD: Hamilton Depression Rating Scale HPA: Hypothalamic-pituitary-adrenal IDO: Indoleamine 2,3-dioxygenase KAT: Kynurenine aminotransferase KMO: Kynurenine 3-monooxygenase KP: Kynurenine pathway K-SADS-PL: Schedule for Affective Disorders and Schizophrenia for School-Age Children KYN: Kynurenine KYNA: Kynurenic acid LDH: Lactate dehydrogenase LPS: Lipopolysaccharide LSD: Lysergic acid diethylamide MDD: Major depressive disorder NMDAR: N-methyl-D-aspartate receptor NO: Nitric oxide PA: Picolinic acid QA: Quinolinic acid ROS: Reactive oxygen species SCFA: Short-chain fatty acids SSRI: Selective serotonin reuptake inhibitor TBI: Traumatic brain injury TDO : Tryptophan 2,3-dioxygenase TRP: Tryptophan UCMS: Unpredictable Chronic Mild Stress References Cipriani A, Furukawa TA, Salanti G, Chaimani A, Atkinson LZ, Ogawa Y, et al

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Figure 2 Structure of different PLC isoforms In mammals, 13 different PLC isozymes have been reported and are divided into six different subfamilies, namely , , , , , and (Suh et al., 2008

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The invention has the following advantages: (1) the final product prepared by the invention is a product which is quantitatively frozen and dried in a tube-shaped bottle according to the product specification, and the invention adopts a repeated freezing and thawing process, has white and porous block appearance, better stability and less single impurity and total impurity

1 This compounded sublingual semaglutide is formulated with a base that may help improve absorption through the lining of the mouth