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The PI3K pathway activated by IGF1R usually alters in cancer cells (Cairns et al., 2011), which not only provides anti-apoptotic and mitogenic signals but also affects cancer cell metabolism, in this process, Akt, the downstream target of PI3K, has been shown to stimulate the glycolytic pathway, favoring energy production in the tumors (Plas and Thompson, 2005)
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Safety and Efficacy of Alpha Lipoic Acid During 4 Years of Observation: A Retrospective, Clinical Trial in Healthy Subjects in Primary Prevention
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10.1038/s41386-018-0010-3 26 HernandezN
Lab Anim Sci 32, 15762
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