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10.1007/s10787-017-0323-6 50 MihovilI.RadicB.BrcicL.BrcicI.VukojaI.IlicS.et al (2009)
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Based on the fact that IR and IGF-1R are abundantly expressed in chondrocytes 27,28 and the previous work which showed upregulation of IR signaling in osteoblasts lacking IGF-1R, 12 we suspected that the increased proliferation of IR-deficient growth plate chondrocytes could be caused by upregulation of the IGF-1/IGF-1R signaling pathway
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