retatrutide gip glp-1 glucagon receptor agonist Retatrutide: How Triple GLP-1/GIP/Glucagon Agonism Differs From Existing Compounds Retatrutide and Insulin Resistance in

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The cryo-EM structures of retatrutide-bound GLP-1R, GIPR and GCGR reveal a combination of conserved peptidereceptor interactions and receptor-specific conformations, particularly in ECL1, that enables retatrutide to execute agonism at multiple receptors