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For better bioavailability, look for formulations that include piperine (black pepper extract) or use technologies like liposomal delivery or nanoparticles

Contraindications: Active malignancy (GH/IGF-1 can promote tumor growth), pregnancy (Category Xevidence of fetal risk), hypersensitivity to tesamorelin or mannitol

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doi: 10.3390/ijms22157765

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Both require ongoing intervention: surgery needs lifelong lifestyle adherence, retatrutide needs continued medication (stopping leads to fat reaccumulation)

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